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As the transporter cycles through the stages of ATP binding, hydrolysis and product dissociation, the interface between the two ABC domains switches from a closed interface, with the bound ATP.
Here we review evidence for the contribution of cytokines to acute neurodegeneration, focusing primarily on interleukin 1 (IL-1), tumour necrosis factor- (TNF) and transforming growth factor.
As numerous cellular context-dependent factors tightly maintain the balance of TGF signalling and contribute to the regulation of TGF-induced cell responses, in this Review we discuss how they.
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This Review deals with recent progress in the immunotherapy of established (pre)malignant disease of viral or non-viral origin by synthetic vaccines capable of inducing robust T-cell responses.
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